Folate deficiency is one of the most common vitamin deficiencies. In individuals with homozygous (TT) or heterozygous (CT) genetic predisposition, eating folate-rich foods may not provide the recommended daily dosage of folate; thus the need for supplementation. By providing 5-methylfolate directly, 5-MTHF Plus Forte® may have benefits for those who do not produce enough 5-methylfolate in response to folic acid supplementation.